Store narcan nasal spray in the blister and cartons provided. If giving to a child, make sure the nozzle seals the nostril. Administer narcan nasal spray in alternate nostrils with each dose. Opioid overdose reversal with naloxone narcan, evzio. For more information on narcan nasal spray, visit narcannasalspray. Know the signs of overdose person is passed out and you cannot wake them up. Buprenorphine sublingual tablet dosing should be initiated preferably when moderate objective signs of opioid withdrawal. Narcan nasal spray 4 mg is supplied as carton containing two 2 blister packages ndc 6954735302 each with a single spray device. Since most accidental overdoses occur in a home setting, it was developed for first responders. Inactive ingredients include benzalkonium chloride preservative, disodium ethylenediaminetetraacetate stabilizer, sodium chloride.
There is 1 small study listed in the narcan nasal spray prescribing information that compares in narcan with traditional unbranded im naloxone in the gluteus maximus muscle. If you suspect an opioid overdose, administer narcan nasal spray and get emergency medical assistance right away. With the vial upside down, pull back plunger and draw up 1ml 1cc of naloxone. Mylan manufactures naloxone hydrochloride injection, usp narcan in strengths of 04 mgml4 mg. There was no statistically significant difference between the times to maximum concentration achieved by any of the naloxone formulationsmeaning that they are all. Remove narcan nasal spray from the box peel back the tab to remove the device from the packaging hold the narcan nasal spray with your thumb on the bottom, middle and index finger on either side of the nozzle peel place press tilt the persons head back and support their neck with your hand insert the tip of the nozzle. Apr 25, 2018 muse alprostadil is a singleuse, medicated transurethral system for the delivery of alprostadil to the male urethra. Naloxone vial may only have one dose, or may be a multidose vial. Bleeding risk coumadin warfarin sodium can cause major or fatal bleeding see warnings and precautions 5. Strattera is not approved for major depressive disorder.
Upon activation, the needle is automatically inserted, delivers the injection, and then retracts fully into its housing. For opioidinduced respiratory depression, dilute with sterile water for injection. If they are not waking up or breathing normally within 23 minutes, use the second nasal spray in the package. Dbl naloxone hydrochloride injection usp 400 microgramsml solution for injection. Anyone who may have to use naloxone should carefully read the package insert that comes with the product. Gently insert the nozzle into either one of the persons nostrils, until your fingers are touching the bottom of the persons nose.
It markedly attenuates or completely blocks, reversibly, the subjective effects of intravenously administered. Neonatal opioid withdrawal syndrome nows is an expected and treatable outcome of prolonged use of opioids during pregnancy. Narcan nasal spray is indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory andor central nervous system depression. The hydrochloride salt is soluble in water to the extent of about 100 mgml. Limitations of use maxalt should only be used where a clear diagnosis of migraine has been established. Narcan nasal spray is to be given right away and does not take the place of emergency medical care. Antepartum fetalmaternal hemorrhage suspected or proven as a result of placenta previa, amniocentesis, chorionic villus sampling, percutaneous. Adjust the dose based on the patients inr and the condition being treated. Naloxone hydrochloride injection, usp narcan 04 mgml4.
Alprostadil is suspended in polyethylene glycol 1450 as excipient and is formed into a medicated pellet microsuppository measuring 1. Administer a naloxone product per package insert instructions. Requests for narcan naloxone nasal spray may be approved when the following criteria are met. Maxalt is 5mg in patients weighing less than 40 kg 88lb, and 10 mg in patients weighing 40 kg 88lb or more. Usual amounts of narcan for reversing an opioid overdose in children are based on body weight. Gently insert the tip of the nozzle into one nostril. The physician prescribing information also is available. Firmly press the plunger to give the dose of narcan. Indicated for immediate administration as emergency treatment of known or suspected opioid overdose, as manifested by respiratory andor central nervous system depression. Highlights of prescribing information these highlights do not include all the information needed to use sublocadesafely and effectively. Naloxone hydrochloride prevents or reverses the effects of opioids, including respiratory depression, sedation, and hypotension. May 15, 2015 the pi is different from the patient package insert ppi, which contains information intended for patients, notwithstanding that the ppi may be required as part of the fdaapproved labeling for the drug.
Hold the device with your thumb on the bottom of the plunger and 2 fingers. Dbl naloxone hydrochloride, solution for injection medsafe. Instructions for use how to use narcan nasal spray. Prescribing information suboxone buprenorphine and. Including patient medication information narcan nasal spray. Naloxone hydrochloride, usp is chemically designated 17allyl4,5. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. Narcan nasal spray is not made with natural rubber latex. Page 2 of 21 full prescribing information 1 indications and usage 1. Naloxone hydrochloride naloxone hydrochloride pfizer. Capitals indicate lifethreatening, underlines indicate most frequent. Belbuca should not be used if the package seal is broken or the film is cut, damaged, or changed in any way.
Each narcan nasal spray contains a 2 mg or 4 mg single dose of naloxone hydrochloride equivalent to 1. Narcan naloxone hcl nasal spray is used for the treatment of an opioid emergency or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond. Suboxone sublingual film contains buprenorphine, a partial. The dosage and administration of coumadin must be individualized for each patient according to the patients international normalized ratio inr response to the drug. Insert the needle into the muscle of the upper arm or thigh of the victim, through the clothing if needed, and push the plunger to inject all of the naloxone. Remove the nozzle from the nostril after giving the dose and lay the person on their side.
Duration oftherapy is based on recovery from neutropenia or immunosuppression. Narcan, evzio naloxone dosing, indications, interactions. Drug treatment may not be indicated for all patients with this syndrome. Naloxone hydrochloride injection is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids including propoxyphene, methadone, and certain mixed agonistantagonist analgesics. This product information is intended only for residents of the united states. Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and. Information for health care professionals about nexium esomeprazole magnesium packets for delayedrelease oral suspension, a treatment for gerd and related conditions. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group.
On day 2, administer up to 16 mg4 mg of suboxone sublingual film as a single dose. Lunesta is a cns depressant and can impair daytime function in some patients at the higher doses 2 mg or 3 mg, even when used as prescribed. Perform regular monitoring of inr in all treated patients see dosage and administration 2. If the first dose does not seem adequate, a larger, 0. Overrides approval duration prior authorization 1 year. Opioid overdose responsenaloxone administration training. Please read the patient information for nuvaring etonogestrelethinyl estradiol vaginal ring, including the information about the increased risk of serious cardiovascular side effects, especially in women who smoke, and discuss it with your health care provider. Symptomatic response to therapy does not rule out the presence of gastric malignancy. These highlights do not include all the information needed to. These highlights do not include all the information needed to use narcan nasal spray safely and. Opioid overdose responsenaloxone administration training training objectives understand administration of naloxone products, including good samaritan protection law recognize the signs of an opioid overdose and identify its causes and risks describe what not to do during an opioid overdose. Chronic use of opioids may influence the hypothalamicpituitarygonadal axis, leading to androgen deficiency that may manifest as symptoms as low libido, impotence, erectile dysfunction, amenorrhea, or infertility. To be prescribed only by health care providers knowledgeable in use of potent opioids for management of chronic pain. Naloxone in the district of columbia a training for.
How to use naloxone nasal spray narcan naloxone for. Nexium is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles and in patients receiving rilpivirinecontaining products. Narcan nasal spray is a pure opioid antagonist indicated for emergency use outside of a hospital to reverse known or suspected opioid overdose, as manifested by respiratory andor severe central nervous system depression. Administer undiluted for suspected opioid overdose. Taking lunesta with or immediately after a heavy, highfat meal results in slower absorption and would be expected to reduce the effect of lunesta on sleep latency see clinical pharmacology 12. Product monograph pr reviatm naltrexone hydrochloride tablets, 50 mg therapeutic classification opioid antagonist action and clinical pharmacology pharmacodynamic actions revia naltrexone hydrochloride is a pure opioid antagonist. Strattera is indicated as an integral part of a total treatment program for adhd that may include other measures psychological, educational, social for patients with this syndrome. As of 11216, narcan nasal spray has been approved by the fda, but is not yet publicly available. Injectable and intranasal branded2 injectable generic3.
Highlights of prescribing information maoainhibitorused in. Highlights of prescribing information serious cardiac. Menopur is a gonadotropin for injection designed to be administered subcutaneously under the skin, as part of an assisted reproductive technology art cycle. Product monograph template standard how to use narcan. Naloxone injection fda prescribing information, side. Prescribers should monitor for excess depressant effects, but impairment can occur in the absence of symptoms or even with. Pooled analyses of shortterm 6 to 18weeks placebocontrolled trials of strattera in children and adolescents a total of 12trials involving over 2200 patients, including 11 trials in adhd and 1 trial in enuresis. If diagnosed, treat with physiologic replacement of corticosteroids, and weanpatient off of the opioid.
Using a needle at least 1 inch long, inject into muscle in the upper arm. Narcan fda prescribing information, side effects and uses. Norco hydrocodone bitartrate and acetaminophen tablets. The study examined 30 healthy inpatients and compared 1 dose of narcan in 4 mg0.
Narcan naloxone nasal spray was developed to be used at home without the need for any medical training. Nexium esomeprazole magnesium packets gerd and related. Naloxone, an opioid antagonist, is a synthetic congener of oxymorphone. The dose varies depending on the formulation, and sometimes more than one dose is needed to help the person start breathing again. Drug treatment is not intended for use in the patient who exhibits symptoms secondary to. First, the patient must use the tongue to wet the inside of the cheek or rinse the mouth with water to wet the area for placement of belbuca. Narcan nasal spray is intended for immediate administration as emergency therapy in settings where opioids may be present. Highlights of prescribing information buprenorphine.
Highlights of prescribing information these highlights do not. It differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group. Belbuca is then applied immediately after removal from the individually sealed package. Feb 26, 2020 naloxone hydrochloride injection, usp may be administered intravenously, intramuscularly, or subcutaneously. Readminister narcan nasal spray, using a new nasal spray, every 2 to 3 minutes if the patient does not respond or responds and then relapses into respiratory depression. The efficacy and safety of treatment with more than one dose of maxalt within 24 hours in pediatric patients 6to 17 years of age have not been established. Narcan nasal spray can be administered by a bystander nonhealthcare professional before emergency medical assistance.
Administer narcan nasal spray according to the printed instructions on the device label and the. These highlights do not include all the information needed. Dailymed naloxone hydrochloride injection, solution. Narcan naloxone hcl nasal spray is the first and only fdaapproved nasal form of naloxone for the emergency treatment of a known or suspected opioid overdose. Narcan naloxone nasal spray will be used to treat known or suspected opioid overdose. Naloxone statewide protocol iowa board of pharmacy. Norco hydrocodone bitartrate and acetaminophen tablets, usp. Prescribing information for nuvaring etonogestrelethinyl. Naloxone hydrochloride injection, solution dailymed. Narcan nasal spray counteracts the lifethreatening effects of an opioid overdose. Naloxone 400 microgramml solution for injection or infusion naloxone hydrochloride. Menopur menotropins for injection ferring reproductive. Detach patients instructions for use from package insert and dispense with product.
Equilibrate the refrigerated vial of noxafilposaconazoleinjectionto room temperature. You can find copies of the package insert for evzio and narcan nasal spray on the fda website. Naloxone hydrochloride injection, usp is a sterile, nonpyrogenic solution of naloxone hydrochloride in water for injection. Each vial of menopur contains equal amounts 75 iu of fsh and hcgdriven lh activity. Revia is available in scored filmcoated tablets containing 50 mg of naltrexone hydrochloride. Naloxone hydrochloride injection, usp narcan 04 mgml4 mg. Insert the needle through the rubber membrane on the naloxone vial, turn the vial upside down, draw up 1ml 1cc of naloxone liquid, and withdraw the needle. Authority this standing order is issued pursuant to act 9 of 2014 act 9 amending the controlled. Narcan nasal spray page 1 of 28 product monograph including patient medication information narcantm nasal spray naloxone hydrochloride nasal spray 2 mg0. The pi is different from the patient package insert ppi, which contains information intended for patients, notwithstanding that the ppi may be required as part of the fdaapproved labeling for the drug.
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